FBXW8

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.^[5][6][7]

FBXW8
Identifiers
Aliases	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDs	OMIM: 609073; MGI: 1923041; HomoloGene: 17731; GeneCards: FBXW8; OMA:FBXW8 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.22 Start 116,910,950 bp[1] End 117,031,148 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 118,203,030 bp[2] End 118,293,529 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gonad ventricular zone bone marrow cell islet of Langerhans ganglionic eminence epithelium of colon testicle popliteal artery tibial arteries Top expressed in otic vesicle otic placode saccule interventricular septum internal carotid artery external carotid artery somite calvaria yolk sac lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component perinuclear region of cytoplasm Golgi apparatus Cul7-RING ubiquitin ligase complex SCF ubiquitin ligase complex 3M complex cytoplasm cytosol Biological process cell population proliferation positive regulation of dendrite morphogenesis spongiotrophoblast layer development labyrinthine layer blood vessel development Golgi organization protein ubiquitination protein polyubiquitination post-translational protein modification positive regulation of transcription factor catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26259 231672 Ensembl ENSG00000174989 ENSMUSG00000032867 UniProt Q8N3Y1 Q8BIA4 RefSeq (mRNA) NM_012174 NM_153348 NM_172721 RefSeq (protein) NP_036306 NP_699179 NP_766309 Location (UCSC) Chr 12: 116.91 – 117.03 Mb Chr 5: 118.2 – 118.29 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[7]