FCGR1A

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.^[5][6][7]

FCGR1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4W4O, 4X4M, 4ZNE
Identifiers
Aliases	FCGR1A, CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia
External IDs	OMIM: 146760; MGI: 95498; HomoloGene: 475; GeneCards: FCGR1A; OMA:FCGR1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,782,671 bp[1] End 149,792,518 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 41.72 cM Start 96,190,225 bp[2] End 96,201,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood placenta right coronary artery appendix C1 segment substantia nigra testicle bone marrow Top expressed in stroma of bone marrow lumbar subsegment of spinal cord calvaria interventricular septum spleen CA3 field embryo granulocyte dermis mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding IgG binding Cellular component integral component of membrane clathrin-coated endocytic vesicle membrane early endosome membrane membrane plasma membrane Biological process immune system process phagocytosis, engulfment antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent immune response Fc-gamma receptor signaling pathway involved in phagocytosis signal transduction regulation of immune response interferon-gamma-mediated signaling pathway receptor-mediated endocytosis innate immune response positive regulation of protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2209 14129 Ensembl ENSG00000150337 ENSMUSG00000015947 UniProt P12314 P26151 RefSeq (mRNA) NM_000566 NM_010186 RefSeq (protein) NP_000557 NP_001365733 NP_001365734 NP_001365735 NP_001365736 NP_001365737 NP_001365738 NP_001365739 NP_001365740 NP_034316 Location (UCSC) Chr 1: 149.78 – 149.79 Mb Chr 3: 96.19 – 96.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.^[8]