FCGR2A

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.^[5][6]

FCGR2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FCG, 1H9V, 3D5O, 3RY4, 3RY5, 3RY6
Identifiers
Aliases	FCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
External IDs	OMIM: 146790; MGI: 95500; HomoloGene: 47936; GeneCards: FCGR2A; OMA:FCGR2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,505,430 bp[1] End 161,524,013 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 78.8 cM Start 170,878,743 bp[2] End 170,892,504 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte placenta appendix right lung metanephric glomerulus spleen upper lobe of left lung gallbladder Top expressed in granulocyte stroma of bone marrow spermatocyte blood calvaria umbilical cord seminiferous tubule dermis right lung lobe tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding IgG binding Cellular component integral component of membrane plasma membrane membrane secretory granule membrane cell wall Biological process Fc-gamma receptor signaling pathway involved in phagocytosis immune system process neutrophil degranulation cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2212 14131 Ensembl ENSG00000143226 ENSMUSG00000059498 UniProt P12318 P08508 RefSeq (mRNA) NM_001136219 NM_021642 NM_001375296 NM_001375297 NM_010188 NM_001356511 RefSeq (protein) NP_001129691 NP_067674 NP_001362225 NP_001362226 n/a Location (UCSC) Chr 1: 161.51 – 161.52 Mb Chr 1: 170.88 – 170.89 Mb PubMed search [3] [4]
Wikidata
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Interactions

FCGR2A has been shown to interact with PIK3R1^[7][8] and Syk.^[8][9]

See also

• CD32