FCGR3A

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.^[5][6] It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

FCGR3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AY4, 3SGJ, 3SGK, 3WN5, 5D6D, 5BW7
Identifiers
Aliases	FCGR3A, CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, Fc fragment of IgG receptor IIIa, Fc gamma receptor IIIa, FcGRIIIA, CD16-II
External IDs	OMIM: 146740; MGI: 2179523; HomoloGene: 477; GeneCards: FCGR3A; OMA:FCGR3A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,541,759 bp[1] End 161,550,737 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 78.53 cM Start 170,846,489 bp[2] End 170,857,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen appendix placenta right lung upper lobe of left lung C1 segment left adrenal gland Top expressed in granulocyte ileum jejunum spleen liver ovary secondary oocyte bone marrow adrenal gland embryo More reference expression data BioGPS n/a
Gene ontology Molecular function IgG binding Cellular component integral component of membrane extracellular region plasma membrane extracellular exosome external side of plasma membrane membrane Biological process immune response Fc-gamma receptor signaling pathway involved in phagocytosis regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2214 246256 Ensembl ENSG00000203747 ENSMUSG00000059089 UniProt P08637 A0A0B4J1G0 RefSeq (mRNA) NM_000569 NM_001127592 NM_001127593 NM_001127595 NM_001127596 NM_001329120 NM_001329122 NM_001386450 NM_144559 NM_180961 RefSeq (protein) NP_000560 NP_001121064 NP_001121065 NP_001121067 NP_001121068 NP_001316049 NP_001316051 NP_653142 Location (UCSC) Chr 1: 161.54 – 161.55 Mb Chr 1: 170.85 – 170.86 Mb PubMed search [3] [4]
Wikidata
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