FCGR3B

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.^[5]

FCGR3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E4J, 1E4K, 1FNL, 1T83, 1T89
Identifiers
Aliases	FCGR3B, CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb, Fc fragment of IgG receptor IIIb, CD16A, FCGR3A, Fc gamma receptor IIIb, CD16-I
External IDs	OMIM: 610665; MGI: 2179523; HomoloGene: 477; GeneCards: FCGR3B; OMA:FCGR3B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,623,196 bp[1] End 161,631,963 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 78.53 cM Start 170,846,489 bp[2] End 170,857,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood periodontal fiber trabecular bone granulocyte spleen bone marrow palpebral conjunctiva bone marrow cells germinal epithelium right lung Top expressed in granulocyte ileum jejunum spleen liver ovary secondary oocyte bone marrow adrenal gland embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function IgG binding Cellular component anchored component of membrane extracellular exosome membrane extracellular region plasma membrane secretory granule membrane Biological process immune response C-terminal protein lipidation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2215 246256 Ensembl ENSG00000162747 ENSMUSG00000059089 UniProt O75015 A0A0B4J1G0 RefSeq (mRNA) NM_001271037 NM_000570 NM_001244753 NM_001271035 NM_001271036 NM_144559 NM_180961 RefSeq (protein) NP_000561 NP_001231682 NP_001257964 NP_001257965 NP_001257966 NP_653142 Location (UCSC) Chr 1: 161.62 – 161.63 Mb Chr 1: 170.85 – 170.86 Mb PubMed search [3] [4]
Wikidata
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Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.^[6]

See also

• CD16
• Cluster of differentiation