FCHSD2

FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene.^[5][6][7]

FCHSD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DL5, 2DL7
Identifiers
Aliases	FCHSD2, NWK, SH3MD3, FCH and double SH3 domains 2, NWK1
External IDs	OMIM: 617556; MGI: 2448475; HomoloGene: 8887; GeneCards: FCHSD2; OMA:FCHSD2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,836,745 bp[1] End 73,142,318 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,742,070 bp[2] End 100,933,612 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries lymph node right coronary artery Descending thoracic aorta ascending aorta ventricular zone right lung left coronary artery appendix Top expressed in zygote mesenteric lymph nodes secondary oocyte primary oocyte habenula paraventricular nucleus of hypothalamus otolith organ trigeminal ganglion utricle epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding lipid binding Cellular component neuromuscular junction recycling endosome plasma membrane clathrin-coated pit stereocilium shaft cytoplasm membrane cell junction stereocilium cell projection Biological process neuromuscular synaptic transmission regulation of actin filament polymerization positive regulation of actin filament polymerization clathrin-dependent endocytosis positive regulation of Arp2/3 complex-mediated actin nucleation endocytosis protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9873 207278 Ensembl ENSG00000137478 ENSMUSG00000030691 UniProt O94868 Q3USJ8 RefSeq (mRNA) NM_014824 NM_001146010 NM_199012 RefSeq (protein) NP_055639 NP_001139482 NP_950177 Location (UCSC) Chr 11: 72.84 – 73.14 Mb Chr 7: 100.74 – 100.93 Mb PubMed search [3] [4]
Wikidata
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Interactions

FCHSD2 has been shown to interact with MAGI1^[8] and C2orf73.^[9]