FCRLA

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.^[5][6]

FCRLA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HWN
Identifiers
Aliases	FCRLA, FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDs	OMIM: 606891; MGI: 2138647; HomoloGene: 13106; GeneCards: FCRLA; OMA:FCRLA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,706,972 bp[1] End 161,714,352 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,745,145 bp[2] End 170,755,152 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum lymph node epithelium of nasopharynx spleen appendix superficial temporal artery pancreatic ductal cell bone marrow cells granulocyte blood Top expressed in spleen mesenteric lymph nodes blood granulocyte spermatocyte bone marrow subcutaneous adipose tissue tibiofemoral joint thymus spermatid More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 84824 98752 Ensembl ENSG00000132185 ENSMUSG00000038421 UniProt Q7L513 Q920A9 RefSeq (mRNA) NM_001184866 NM_001184867 NM_001184870 NM_001184871 NM_001184872 NM_001184873 NM_032738 NM_001366195 NM_001366196 NM_001160215 NM_145141 RefSeq (protein) NP_001171795 NP_001171796 NP_001171799 NP_001171800 NP_001171801 NP_001171802 NP_116127 NP_001353124 NP_001353125 NP_001153687 NP_660123 Location (UCSC) Chr 1: 161.71 – 161.71 Mb Chr 1: 170.75 – 170.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM]^[6]