FEZ1

Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.^[5][6][7]

FEZ1
Identifiers
Aliases	FEZ1, UNC-76, fasciculation and elongation protein zeta 1
External IDs	OMIM: 604825; MGI: 2670976; HomoloGene: 21063; GeneCards: FEZ1; OMA:FEZ1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 125,442,881 bp[1] End 125,592,568 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 36,733,160 bp[2] End 36,790,220 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus C1 segment inferior ganglion of vagus nerve corpus callosum middle frontal gyrus subthalamic nucleus prefrontal cortex Pons dorsal motor nucleus of vagus nerve substantia nigra Top expressed in deep cerebellar nuclei globus pallidus ventricular zone lobe of cerebellum cerebellar vermis inferior colliculi superior colliculus lateral geniculate nucleus ganglionic eminence Medulla Oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding gamma-tubulin binding protein kinase C binding protein N-terminus binding Cellular component centrosome Golgi apparatus cell projection membrane plasma membrane microtubule organizing center dendrite mitochondrion microtubule cytoskeleton cytoplasm axon growth cone soma microtubule cytoskeleton Biological process negative regulation of autophagosome assembly cellular response to growth factor stimulus nervous system development axon guidance cell adhesion establishment of mitochondrion localization positive regulation of neuron differentiation positive regulation of neuron projection development hippocampus development establishment of cell polarity positive regulation of anterograde axonal transport of mitochondrion mitochondrion morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9638 235180 Ensembl ENSG00000149557 ENSMUSG00000032118 UniProt Q99689 Q8K0X8 RefSeq (mRNA) NM_005103 NM_022549 NM_183171 NM_001357610 NM_001357611 NM_001357612 NM_001357613 NM_001357614 RefSeq (protein) NP_005094 NP_072043 NP_898994 NP_001344539 NP_001344540 NP_001344541 NP_001344542 NP_001344543 Location (UCSC) Chr 11: 125.44 – 125.59 Mb Chr 9: 36.73 – 36.79 Mb PubMed search [3] [4]
Wikidata
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This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.^[7]

This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.^[8]

Interactions

FEZ1 has been shown to interact with Protein kinase Mζ,^[9] NBR1^[10] and DISC1.^[11]