NBR1

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.^[5][6]

NBR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WJ6, 2BKF, 2CP8, 2G4S, 2L8J, 2MGW, 2MJ5, 4OLE
Identifiers
Aliases	NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor
External IDs	OMIM: 166945; MGI: 108498; HomoloGene: 7438; GeneCards: NBR1; OMA:NBR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,170,481 bp[1] End 43,211,689 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 65.36 cM Start 101,442,975 bp[2] End 101,472,777 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii amniotic fluid parietal pleura epithelium of nasopharynx germinal epithelium Epithelium of choroid plexus internal globus pallidus jejunal mucosa palpebral conjunctiva visceral pleura Top expressed in ciliary body retinal pigment epithelium spermatid seminiferous tubule lacrimal gland utricle iris pituitary gland motor neuron sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding zinc ion binding protein binding mitogen-activated protein kinase binding ubiquitin binding Cellular component cytoplasm M band autophagosome cytosol late endosome lysosome extracellular exosome membrane cytoplasmic vesicle phagophore assembly site mitochondrion nucleoplasm nuclear body intracellular membrane-bounded organelle Biological process protein complex oligomerization negative regulation of osteoblast differentiation regulation of stress-activated MAPK cascade regulation of bone mineralization macroautophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4077 17966 Ensembl ENSG00000188554 ENSMUSG00000017119 UniProt Q14596 P97432 RefSeq (mRNA) NM_001291571 NM_001291572 NM_005899 NM_031858 NM_031862 NM_001252220 NM_001252222 NM_001252223 NM_008676 RefSeq (protein) NP_001278500 NP_001278501 NP_005890 NP_114068 NP_001239149 NP_001239151 NP_001239152 NP_032702 Location (UCSC) Chr 17: 43.17 – 43.21 Mb Chr 11: 101.44 – 101.47 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.^[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.^[7]

Interactions

NBR1 has been shown to interact with FEZ1.^[8]