FGD2

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.^[5]

FGD2
Identifiers
Aliases	FGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDs	OMIM: 605091; MGI: 1347084; HomoloGene: 8438; GeneCards: FGD2; OMA:FGD2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 37,005,646 bp[1] End 37,029,069 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 15.26 cM|17 A3.3 Start 29,360,914 bp[2] End 29,379,661 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spleen granulocyte epithelium of nasopharynx internal globus pallidus lymph node buccal mucosa cell blood trabecular bone cardia Top expressed in otic vesicle saccule spleen granulocyte blood otic placode islet of Langerhans stroma of bone marrow mesenteric lymph nodes epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol phosphate binding metal ion binding small GTPase binding protein binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol endosome Golgi apparatus cell projection early endosome membrane membrane ruffle plasma membrane ruffle membrane early endosome cytoskeleton nucleus lamellipodium Biological process positive regulation of JUN kinase activity regulation of GTPase activity filopodium assembly cytoskeleton organization regulation of cell shape positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction actin cytoskeleton organization G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221472 26382 Ensembl ENSG00000146192 ENSMUSG00000024013 UniProt Q7Z6J4 Q8BY35 RefSeq (mRNA) NM_173558 NM_001159538 NM_013710 RefSeq (protein) NP_775829 NP_001153010 NP_038738 Location (UCSC) Chr 6: 37.01 – 37.03 Mb Chr 17: 29.36 – 29.38 Mb PubMed search [3] [4]
Wikidata
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It is a member of the FYVE, RhoGEF and PH domain containing family.

See also

• FYVE domain (zinc finger domain)
• RhoGEF domain (with guanine nucleotide exchange factor activity)
• PH domain (pleckstrin homology domain)