FGD3

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.^[5][6]

FGD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COC
Identifiers
Aliases	FGD3, ZFYVE5, FYVE, RhoGEF and PH domain containing 3
External IDs	OMIM: 617554; MGI: 1353657; HomoloGene: 22925; GeneCards: FGD3; OMA:FGD3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 92,947,523 bp[1] End 93,036,236 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 25.18 cM Start 49,415,030 bp[2] End 49,473,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood thymus monocyte spleen bone marrow cells trabecular bone pancreatic ductal cell lymph node appendix Top expressed in granulocyte gastrula yolk sac embryo thymus visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex primary visual cortex submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding small GTPase binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol Golgi apparatus ruffle cytoskeleton lamellipodium Biological process regulation of GTPase activity filopodium assembly cytoskeleton organization regulation of cell shape positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction actin cytoskeleton organization G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89846 30938 Ensembl ENSG00000127084 ENSMUSG00000037946 UniProt Q5JSP0 O88842 RefSeq (mRNA) NM_001083536 NM_001286993 NM_033086 NM_001369951 NM_001369952 NM_015759 RefSeq (protein) NP_001077005 NP_001273922 NP_149077 NP_001356880 NP_001356881 NP_001077005.1 NP_149077.2 n/a Location (UCSC) Chr 9: 92.95 – 93.04 Mb Chr 13: 49.42 – 49.47 Mb PubMed search [3] [4]
Wikidata
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See also

• FYVE, RhoGEF and PH domain containing
  • FYVE domain (zinc finger domain)
  • RhoGEF domain (with guanine nucleotide exchange factor activity)
  • PH domain (pleckstrin homology domain)