FGF7

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.^[5][6][7]

FGF7
Identifiers
Aliases	FGF7, HBGF-7, KGF, fibroblast growth factor 7
External IDs	OMIM: 148180; MGI: 95521; HomoloGene: 7316; GeneCards: FGF7; OMA:FGF7 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 49,423,237 bp[1] End 49,488,775 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 125,876,578 bp[2] End 125,933,105 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon stromal cell of endometrium gallbladder epithelium of colon tibial nerve canal of the cervix left uterine tube body of uterus sural nerve ectocervix Top expressed in stroma of bone marrow calvaria lobe of cerebellum cerebellar vermis endothelial cell of lymphatic vessel intercostal muscle left lung lobe ankle myotome detrusor urinae muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding fibroblast growth factor receptor binding protein binding chemoattractant activity growth factor activity 1-phosphatidylinositol-3-kinase activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component Golgi apparatus extracellular region Biological process actin cytoskeleton reorganization mesenchymal cell proliferation positive regulation of keratinocyte proliferation positive regulation of epithelial cell proliferation involved in lung morphogenesis secretion by lung epithelial cell involved in lung growth positive regulation of epithelial cell proliferation regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling MAPK cascade positive regulation of transcription, DNA-templated fibroblast growth factor receptor signaling pathway positive regulation of keratinocyte migration protein localization to cell surface response to wounding positive regulation of cell population proliferation epidermis development positive regulation of peptidyl-tyrosine phosphorylation hair follicle morphogenesis positive chemotaxis positive regulation of cell division signal transduction branching involved in salivary gland morphogenesis phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2252 14178 Ensembl ENSG00000140285 ENSMUSG00000027208 UniProt P21781 P36363 RefSeq (mRNA) NM_002009 NM_008008 RefSeq (protein) NP_002000 NP_032034 Location (UCSC) Chr 15: 49.42 – 49.49 Mb Chr 2: 125.88 – 125.93 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.^[7]

Interactions

FGF7 has been shown to interact with Perlecan.^[8]