FGFBP1

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.^[5][6][7]

FGFBP1
Identifiers
Aliases	FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1
External IDs	OMIM: 607737; MGI: 1096350; HomoloGene: 3766; GeneCards: FGFBP1; OMA:FGFBP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.32 Start 15,935,577 bp[1] End 15,938,740 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 44,136,200 bp[2] End 44,139,121 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx gums gingival epithelium mucosa of esophagus oral cavity mucosa of transverse colon human penis vulva skin of abdomen skin of leg Top expressed in corneal stroma mucous cell of stomach skin of abdomen epithelium of stomach optic nerve esophagus umbilical cord lip pyloric antrum left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibroblast growth factor binding heparin binding protein binding growth factor binding Cellular component extracellular region cell surface plasma membrane membrane extracellular space Biological process positive regulation of fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway signal transduction positive regulation of cell population proliferation negative regulation of cell population proliferation cell-cell signaling positive regulation of cell migration involved in sprouting angiogenesis positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9982 14181 Ensembl ENSG00000137440 ENSMUSG00000048373 UniProt Q14512 O70514 RefSeq (mRNA) NM_005130 NM_001271616 NM_008009 RefSeq (protein) NP_005121 NP_001258545 NP_032035 Location (UCSC) Chr 4: 15.94 – 15.94 Mb Chr 5: 44.14 – 44.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).[supplied by OMIM]^[7]

Interactions

FGFBP1 has been shown to interaction with Perlecan.^[5]