FGFR1OP

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.^[5][6][7]

CEP43
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D68
Identifiers
Aliases	CEP43, FOP, FGFR1 oncogene partner, centrosomal protein 43, FGFR1OP
External IDs	OMIM: 605392; MGI: 1922546; HomoloGene: 5116; GeneCards: CEP43; OMA:CEP43 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 166,999,317 bp[1] End 167,094,789 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 8,384,333 bp[2] End 8,415,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte tendon of biceps brachii right uterine tube left testis right testis buccal mucosa cell endometrium internal globus pallidus bronchial epithelial cell Top expressed in otic vesicle hand otolith organ utricle spermatocyte primitive streak Paneth cell hair follicle mandibular prominence maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity protein tyrosine kinase inhibitor activity protein binding protein tyrosine kinase activity protein kinase binding Cellular component cytoplasm cytosol centrosome microtubule organizing center perinuclear region of cytoplasm cytoskeleton nucleus centriole cell projection Biological process negative regulation of protein kinase activity positive regulation of cell migration positive regulation of cell growth microtubule anchoring G2/M transition of mitotic cell cycle positive regulation of cell population proliferation peptidyl-tyrosine phosphorylation negative regulation of protein tyrosine kinase activity ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle cell projection organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11116 75296 Ensembl ENSG00000213066 ENSMUSG00000069135 UniProt O95684 Q66JX5 RefSeq (mRNA) NM_194429 NM_001278690 NM_007045 NM_001197046 NM_201230 RefSeq (protein) NP_001265619 NP_008976 NP_919410 NP_001183975 NP_957682 Location (UCSC) Chr 6: 167 – 167.09 Mb Chr 17: 8.38 – 8.42 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.^[7]