FKBP10

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.^[5][6][7]

FKBP10
Identifiers
Aliases	FKBP10, FKBP65, OI11, OI6, PPIASE, hFKBP65, BRKS1, FK506 binding protein 10, FKBP prolyl isomerase 10
External IDs	OMIM: 607063; MGI: 104769; HomoloGene: 7718; GeneCards: FKBP10; OMA:FKBP10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,812,680 bp[1] End 41,823,213 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.47 cM Start 100,306,523 bp[2] End 100,315,650 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ascending aorta Descending thoracic aorta anterior pituitary right coronary artery right ovary canal of the cervix body of uterus left ovary left coronary artery Top expressed in calvaria internal carotid artery external carotid artery body of femur fossa molar vas deferens vestibular sensory epithelium stroma of bone marrow dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding isomerase activity peptidyl-prolyl cis-trans isomerase activity metal ion binding FK506 binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum cytoplasm nucleolus Biological process chaperone-mediated protein folding histone peptidyl-prolyl isomerization peptidyl-proline modification protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60681 14230 Ensembl ENSG00000141756 ENSMUSG00000001555 UniProt Q96AY3 Q61576 RefSeq (mRNA) NM_021939 NM_001163481 NM_010221 RefSeq (protein) NP_068758 NP_001156953 NP_034351 Location (UCSC) Chr 17: 41.81 – 41.82 Mb Chr 11: 100.31 – 100.32 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.^[7]