FKBP2

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.^[5][6]

FKBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PBC, 4NNR
Identifiers
Aliases	FKBP2, FKBP-13, PPIase, FK506 binding protein 2, FKBP prolyl isomerase 2, FKBP13
External IDs	OMIM: 186946; MGI: 95542; HomoloGene: 40604; GeneCards: FKBP2; OMA:FKBP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,241,003 bp[1] End 64,244,134 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,955,109 bp[2] End 6,957,869 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary body of pancreas right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon right lobe of liver primary visual cortex hypothalamus human kidney Top expressed in seminal vesicula supraoptic nucleus choroid plexus of fourth ventricle islet of Langerhans lobe of prostate parotid gland right kidney medulla oblongata medial vestibular nucleus yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function FK506 binding protein binding isomerase activity peptidyl-prolyl cis-trans isomerase activity Cellular component membrane endoplasmic reticulum endoplasmic reticulum membrane Biological process chaperone-mediated protein folding protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2286 14227 Ensembl ENSG00000173486 ENSMUSG00000056629 UniProt P26885 P45878 RefSeq (mRNA) NM_001135208 NM_004470 NM_057092 NM_001166368 NM_008020 NM_001360286 NM_001360288 RefSeq (protein) NP_001128680 NP_004461 NP_476433 NP_001159840 NP_032046 NP_001347215 NP_001347217 Location (UCSC) Chr 11: 64.24 – 64.24 Mb Chr 19: 6.96 – 6.96 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.^[6]

Interactions

FKBP2 has been shown to interact with ARFGEF1^[7] and EPB41L2.^[8]