FKBP8

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.^[5][6]

FKBP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AWG, 2D9F, 2F2D, 2MF9, 3EY6
Identifiers
Aliases	FKBP8, FKBP38, FKBPr38, FK506 binding protein 8, FKBP prolyl isomerase 8
External IDs	OMIM: 604840; MGI: 1341070; HomoloGene: 7720; GeneCards: FKBP8; OMA:FKBP8 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,531,751 bp[1] End 18,544,077 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,980,374 bp[2] End 70,987,978 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right testis left testis right hemisphere of cerebellum anterior pituitary C1 segment cingulate gyrus anterior cingulate cortex muscle layer of sigmoid colon right uterine tube Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex spermatocyte neural layer of retina granulocyte lip perirhinal cortex entorhinal cortex ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function FK506 binding isomerase activity peptidyl-prolyl cis-trans isomerase activity metal ion binding protein binding identical protein binding disordered domain specific binding Cellular component integral component of membrane membrane mitochondrial membranes integral component of endoplasmic reticulum membrane mitochondrial envelope mitochondrion endoplasmic reticulum cytosol cytoplasm protein-containing complex Biological process apoptotic process intracellular signal transduction multicellular organism growth cell fate specification negative regulation of apoptotic process regulation of BMP signaling pathway neural tube development positive regulation of BMP signaling pathway regulation of gene expression smoothened signaling pathway camera-type eye development dorsal/ventral neural tube patterning viral process dorsal/ventral pattern formation chaperone-mediated protein folding protein peptidyl-prolyl isomerization negative regulation of protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23770 14232 Ensembl ENSG00000105701 ENSMUSG00000019428 UniProt Q14318 O35465 RefSeq (mRNA) NM_001308373 NM_012181 NM_001111066 NM_001199631 NM_010223 RefSeq (protein) NP_001295302 NP_036313 NP_001295302.1 NP_001104536 NP_001186560 NP_034353 Location (UCSC) Chr 19: 18.53 – 18.54 Mb Chr 8: 70.98 – 70.99 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.^[6]