FKBPL

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.^[5]

FKBPL
Identifiers
Aliases	FKBPL, DIR1, NG7, WISP39, FKBP4, FK506 binding protein like, FKBP prolyl isomerase like
External IDs	OMIM: 617076; MGI: 1932127; HomoloGene: 10529; GeneCards: FKBPL; OMA:FKBPL - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,128,707 bp[1] End 32,130,288 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 34,863,738 bp[2] End 34,865,298 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad skin of leg granulocyte skin of abdomen mucosa of transverse colon islet of Langerhans apex of heart body of stomach blood Top expressed in seminiferous tubule spermatid spermatocyte primary oocyte granulocyte muscle of thigh embryo right kidney secondary oocyte embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol extracellular region Biological process response to radiation protein stabilization regulation of angiogenesis regulation of blood vessel branching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63943 56299 Ensembl ENSG00000204315 ENSG00000230907 ENSG00000224200 ENSG00000223666 ENSMUSG00000033739 UniProt Q9UIM3 O35450 RefSeq (mRNA) NM_022110 NM_019873 RefSeq (protein) NP_071393 NP_071393.2 NP_063926 Location (UCSC) Chr 6: 32.13 – 32.13 Mb Chr 17: 34.86 – 34.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.^[6]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.^[7] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.^[8]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.^[9]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.^[10]