FLOT2

Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene.^[5][6] Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.^[7]

FLOT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WIN
Identifiers
Aliases	FLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2
External IDs	OMIM: 131560; MGI: 103309; HomoloGene: 3293; GeneCards: FLOT2; OMA:FLOT2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,879,335 bp[1] End 28,897,733 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 77,928,757 bp[2] End 77,951,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen blood gastric mucosa apex of heart olfactory zone of nasal mucosa lymph node minor salivary glands right lung Top expressed in ankle joint external carotid artery facial motor nucleus internal carotid artery tunica media of zone of aorta granulocyte dorsomedial hypothalamic nucleus motor neuron carotid body tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding protein binding protein heterodimerization activity ionotropic glutamate receptor binding Cellular component vesicle endosome membrane cell-cell contact zone focal adhesion endocytic vesicle acrosomal membrane flotillin complex uropod basolateral plasma membrane apical plasma membrane cortical actin cytoskeleton perinuclear region of cytoplasm caveola membrane raft extracellular exosome cytoplasmic vesicle lamellipodium plasma membrane dendrite cytoplasm synapse glutamatergic synapse anchored component of presynaptic active zone membrane Biological process positive regulation of establishment of T cell polarity regulation of toll-like receptor 3 signaling pathway regulation of heterotypic cell-cell adhesion protein stabilization negative regulation of amyloid precursor protein catabolic process negative regulation of gene expression protein localization to plasma membrane raft cell adhesion membrane raft assembly regulation of myoblast differentiation epidermis development protein localization to plasma membrane anterograde dendritic transport regulation of postsynaptic membrane neurotransmitter receptor levels positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2319 14252 Ensembl ENSG00000132589 ENSMUSG00000061981 UniProt Q14254 Q60634 RefSeq (mRNA) NM_004475 NM_001330170 NM_001040403 NM_001284227 NM_001284228 NM_008028 NM_001362625 NM_001362626 NM_001362627 RefSeq (protein) NP_001317099 NP_004466 NP_001035493 NP_001271156 NP_001271157 NP_032054 NP_001349554 NP_001349555 NP_001349556 Location (UCSC) Chr 17: 28.88 – 28.9 Mb Chr 11: 77.93 – 77.95 Mb PubMed search [3] [4]
Wikidata
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Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.^[6]