FLVCR2

Feline leukemia virus subgroup C cellular receptor family, member 2 is a protein that in humans is encoded by the FLVCR2 gene.^[5]

FLVCR2
Identifiers
Aliases	FLVCR2, C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH, feline leukemia virus subgroup C cellular receptor family member 2, SLC49A2, FLVCR heme transporter 2
External IDs	OMIM: 610865; MGI: 2384974; HomoloGene: 9840; GeneCards: FLVCR2; OMA:FLVCR2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 75,578,620 bp[1] End 75,663,214 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D2 Start 85,793,313 bp[2] End 85,860,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibial nerve monocyte sperm right testis left testis right adrenal cortex left adrenal cortex mucosa of ileum right lobe of liver Top expressed in retinal pigment epithelium morula morula blastocyst yolk sac spermatid proximal tubule right kidney spermatocyte seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function heme transmembrane transporter activity heme binding Cellular component integral component of membrane plasma membrane membrane Biological process transmembrane transport heme transport heme export Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55640 217721 Ensembl ENSG00000119686 ENSMUSG00000034258 UniProt Q9UPI3 Q91X85 RefSeq (mRNA) NM_017791 NM_001195283 NM_145447 RefSeq (protein) NP_001182212 NP_060261 NP_663422 Location (UCSC) Chr 14: 75.58 – 75.66 Mb Chr 12: 85.79 – 85.86 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1 (FLVCR1), the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome.