FMO5

Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme in humans encoded by the FMO5 gene.^[5][6][7]

FMO5
Identifiers
Aliases	FMO5, flavin containing monooxygenase 5, flavin containing dimethylaniline monoxygenase 5, hBVMO1
External IDs	OMIM: 603957; MGI: 1310004; HomoloGene: 68185; GeneCards: FMO5; OMA:FMO5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 147,175,351 bp[1] End 147,243,050 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 97,536,120 bp[2] End 97,562,598 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver rectum jejunal mucosa buccal mucosa cell duodenum body of pancreas body of stomach mucosa of colon mucosa of sigmoid colon right lung Top expressed in transitional epithelium of urinary bladder left lobe of liver right kidney jejunum granulocyte duodenum olfactory epithelium proximal tubule ileum conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity N,N-dimethylaniline monooxygenase activity NADP binding flavin adenine dinucleotide binding monooxygenase activity Cellular component organelle membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle cytosol Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2330 14263 Ensembl ENSG00000131781 ENSMUSG00000028088 UniProt P49326 P97872 RefSeq (mRNA) NM_001144829 NM_001144830 NM_001461 NM_001161763 NM_001161765 NM_010232 NM_001355119 RefSeq (protein) NP_001138301 NP_001138302 NP_001452 NP_001155235 NP_001155237 NP_034362 NP_001342048 Location (UCSC) Chr 1: 147.18 – 147.24 Mb Chr 3: 97.54 – 97.56 Mb PubMed search [3] [4]
Wikidata
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Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.^[7]

Related gene problems

• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome