FNTB

Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene.^[4][5]

FNTB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37
Identifiers
Aliases	FNTB, FPTB, farnesyltransferase, CAAX box, beta
External IDs	OMIM: 134636; MGI: 1861305; HomoloGene: 1535; GeneCards: FNTB; OMA:FNTB - orthologs
Gene location (Mouse) Chr. Chromosome 12 (mouse)[1] Band 12 C3|12 33.73 cM Start 76,812,363 bp[1] End 76,968,186 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum substantia nigra gastrocnemius muscle tibial nerve skin of abdomen right uterine tube sural nerve pituitary gland hippocampus proper vagina Top expressed in yolk sac lip genital tubercle neural layer of retina tail of embryo muscle of thigh esophagus neural tube cerebellar cortex epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding transferase activity prenyltransferase activity catalytic activity protein farnesyltransferase activity protein binding farnesyltranstransferase activity zinc ion binding isoprenoid binding peptide binding Cellular component cytosol protein farnesyltransferase complex microtubule associated complex protein-containing complex Biological process protein farnesylation positive regulation of cell population proliferation negative regulation of cell population proliferation response to inorganic substance response to organic cyclic compound response to cytokine wound healing positive regulation of cell cycle positive regulation of fibroblast proliferation positive regulation of nitric-oxide synthase biosynthetic process protein prenylation regulation of fibroblast proliferation regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2342 110606 Ensembl n/a ENSMUSG00000033373 UniProt P49356 Q8K2I1 RefSeq (mRNA) NM_002028 NM_145927 RefSeq (protein) NP_002019 NP_001189487 NP_001189488 NP_666039 Location (UCSC) n/a Chr 12: 76.81 – 76.97 Mb PubMed search [2] [3]
Wikidata
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