FOSL1

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.^[5][6]

FOSL1
Identifiers
Aliases	FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDs	OMIM: 136515; MGI: 107179; HomoloGene: 3967; GeneCards: FOSL1; OMA:FOSL1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,892,049 bp[1] End 65,900,573 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.33 cM Start 5,497,575 bp[2] End 5,505,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue stromal cell of endometrium gallbladder vena cava mucosa of urinary bladder mucosa of esophagus testicle islet of Langerhans ascending aorta cervix epithelium Top expressed in endothelial cell of lymphatic vessel granulocyte decidua embryo embryo gastrula stroma of bone marrow supraoptic nucleus lip ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytosol intracellular membrane-bounded organelle neuron projection presynaptic membrane nucleus nucleoplasm Biological process cellular response to extracellular stimulus response to cytokine regulation of transcription, DNA-templated response to organic cyclic compound vitellogenesis regulation of transcription by RNA polymerase II response to progesterone female pregnancy response to corticosterone response to mechanical stimulus response to virus positive regulation of DNA-binding transcription factor activity placenta blood vessel development in utero embryonic development learning positive regulation of DNA-templated transcription, initiation chemotaxis response to gravity cellular defense response positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of apoptotic process response to cAMP response to hydrogen peroxide positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation pri-miRNA transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8061 14283 Ensembl ENSG00000175592 ENSMUSG00000024912 UniProt P15407 P48755 RefSeq (mRNA) NM_001300844 NM_001300855 NM_001300856 NM_001300857 NM_005438 NM_010235 RefSeq (protein) NP_001287773 NP_001287784 NP_001287785 NP_001287786 NP_005429 NP_034365 Location (UCSC) Chr 11: 65.89 – 65.9 Mb Chr 19: 5.5 – 5.51 Mb PubMed search [3] [4]
Wikidata
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Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.^[6]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)^[7] and C-jun.^[7]

See also

• AP-1 (transcription factor)