FOXA3

Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.^[5][6]

FOXA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VTN
Identifiers
Aliases	FOXA3, FKHH3, HNF3G, TCF3G, forkhead box A3
External IDs	OMIM: 602295; MGI: 1347477; HomoloGene: 3308; GeneCards: FOXA3; OMA:FOXA3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,863,989 bp[1] End 45,873,797 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.46 cM Start 18,747,209 bp[2] End 18,757,463 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum right lobe of liver pancreatic ductal cell mucosa of transverse colon body of pancreas mucosa of sigmoid colon rectum cartilage tissue islet of Langerhans palpebral conjunctiva Top expressed in mucous cell of stomach crypt of lieberkuhn of small intestine epithelium of stomach pyloric antrum liver left lobe of liver large intestine left colon yolk sac Hindgut More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding transcription factor binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm actin cytoskeleton nucleus Biological process cellular glucose homeostasis regulation of transcription by RNA polymerase II cellular response to starvation multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated spermatogenesis positive regulation of transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3171 15377 Ensembl ENSG00000170608 ENSMUSG00000040891 UniProt P55318 P35584 RefSeq (mRNA) NM_004497 NM_008260 RefSeq (protein) NP_004488 NP_032286 Location (UCSC) Chr 19: 45.86 – 45.87 Mb Chr 7: 18.75 – 18.76 Mb PubMed search [3] [4]
Wikidata
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Function

HNF-3G is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.^[5]