FOXI3

Forkead box I3 (FOXI3) is a protein that in humans is encoded by the FOXI3 gene. FOXI3 is a forkhead box transcription factor that is expressed in the development of hair and teeth. One of its mutations is a dominant allele responsible for the heterozygous Hh hairless trait in dogs. It was identified in 2008.^[5]

FOXI3
Identifiers
Aliases	FOXI3, forkhead box I3
External IDs	OMIM: 612351; MGI: 3511278; HomoloGene: 52949; GeneCards: FOXI3; OMA:FOXI3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 88,446,787 bp[1] End 88,452,693 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C1 Start 70,933,515 bp[2] End 70,938,050 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad placenta testicle ganglionic eminence anterior pituitary skin of abdomen skin of leg renal cortex Top expressed in pharyngeal pouch cervical loop stellate reticulum hair follicle salivary gland epiblast inner enamel epithelium surface ectoderm embryo lens More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II anatomical structure morphogenesis cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 344167 232077 Ensembl ENSG00000214336 ENSMUSG00000055874 UniProt A8MTJ6 n/a RefSeq (mRNA) NM_001135649 NM_001101464 RefSeq (protein) NP_001129121 n/a Location (UCSC) Chr 2: 88.45 – 88.45 Mb Chr 6: 70.93 – 70.94 Mb PubMed search [3] [4]
Wikidata
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See also

• Chinese Crested Dog
• Mexican Hairless Dog
• Peruvian Inca Orchid (Peruvian Hairless Dog)
• Dog coat genetics