FOXK2

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.^[5][6]

FOXK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JXS, 2C6Y
Identifiers
Aliases	FOXK2, ILF, ILF-1, ILF1, forkhead box K2, nGTBP
External IDs	OMIM: 147685; MGI: 1916087; HomoloGene: 18748; GeneCards: FOXK2; OMA:FOXK2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,519,713 bp[1] End 82,644,662 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 121,259,990 bp[2] End 121,309,896 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle sural nerve ganglionic eminence oocyte muscle of thigh ventricular zone left testis right testis gingival epithelium sperm Top expressed in zygote secondary oocyte cumulus cell ventricular zone ascending aorta renal corpuscle tail of embryo otic vesicle mandibular prominence spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding magnesium ion binding metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytoplasm Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II protein deubiquitination anatomical structure morphogenesis cell differentiation negative regulation of transcription by RNA polymerase II cellular glucose homeostasis negative regulation of autophagy regulation of glucose metabolic process response to starvation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated canonical glycolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3607 68837 Ensembl ENSG00000141568 ENSMUSG00000039275 UniProt Q01167 Q3UCQ1 RefSeq (mRNA) NM_004514 NM_181430 NM_181431 NM_001080932 NM_001363033 RefSeq (protein) NP_004505 NP_001074401 NP_001349962 Location (UCSC) Chr 17: 82.52 – 82.64 Mb Chr 11: 121.26 – 121.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.^[6]