FOXO6

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.^[5]

FOXO6
Identifiers
Aliases	FOXO6, forkhead box O6
External IDs	OMIM: 611457; MGI: 2676586; HomoloGene: 82395; GeneCards: FOXO6; OMA:FOXO6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 41,361,922 bp[1] End 41,383,590 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 120,124,276 bp[2] End 120,144,546 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence pituitary gland anterior pituitary testicle muscle of thigh right ovary left ovary left lobe of thyroid gland body of uterus placenta Top expressed in ganglionic eminence Claustrum ventricular zone subdivision of hippocampus quadriceps femoris muscle nucleus accumbens hippocampus proper skeletal muscle tissue cingulate gyrus Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity sequence-specific DNA binding Cellular component nucleus Biological process transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100132074 329934 Ensembl ENSG00000204060 ENSG00000281518 ENSMUSG00000052135 UniProt A0A1X9RU27 Q70KY4 RefSeq (mRNA) NM_001291281 NM_194060 RefSeq (protein) NP_001278210 NP_918949 Location (UCSC) Chr 1: 41.36 – 41.38 Mb Chr 4: 120.12 – 120.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.^[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 after feeding.^[6] In a condition of insulin resistance, insulin fails to block FoxO6, resulting in continued gluconeogenesis even after feeding.^[6]