FRAT1

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.^[5][6]

FRAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ
Identifiers
Aliases	FRAT1, WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
External IDs	OMIM: 602503; MGI: 109450; HomoloGene: 3999; GeneCards: FRAT1; OMA:FRAT1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 97,319,271 bp[1] End 97,321,915 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 35.3 cM Start 41,818,409 bp[2] End 41,821,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte testicle granulocyte pancreatic ductal cell secondary oocyte gonad right lobe of liver bone marrow spleen Top expressed in spermatid granulocyte muscle of thigh neural layer of retina embryo spermatocyte morula duodenum CA3 field Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol intracellular membrane-bounded organelle cytoplasm Biological process Wnt signaling pathway beta-catenin destruction complex disassembly canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10023 14296 Ensembl ENSG00000165879 ENSMUSG00000067199 UniProt Q92837 P70339 RefSeq (mRNA) NM_181355 NM_005479 NM_008043 RefSeq (protein) NP_005470 NP_032069 Location (UCSC) Chr 10: 97.32 – 97.32 Mb Chr 19: 41.82 – 41.82 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.^[6]