FRAT2

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.^[5][6][7]

FRAT2
Identifiers
Aliases	FRAT2, WNT signaling pathway regulator, FRAT-2, FRAT regulator of WNT signaling pathway 2
External IDs	OMIM: 605006; MGI: 2673967; HomoloGene: 8095; GeneCards: FRAT2; OMA:FRAT2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 97,332,497 bp[1] End 97,334,729 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 35.33 cM Start 41,834,411 bp[2] End 41,836,571 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte granulocyte secondary oocyte mucosa of transverse colon bone marrow trabecular bone jejunal mucosa duodenum palpebral conjunctiva Top expressed in spermatid left colon granulocyte ventricular zone extensor digitorum longus muscle fetal liver hematopoietic progenitor cell vastus lateralis muscle ganglionic eminence knee joint triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component cytosol cellular component cytoplasm Biological process multicellular organism development cell population proliferation Wnt signaling pathway beta-catenin destruction complex disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23401 212398 Ensembl ENSG00000181274 ENSMUSG00000047604 UniProt O75474 Q8K025 RefSeq (mRNA) NM_012083 NM_177603 RefSeq (protein) NP_036215 NP_808271 Location (UCSC) Chr 10: 97.33 – 97.33 Mb Chr 19: 41.83 – 41.84 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.^[7]