FSCN1

Fascin is a protein that in humans is encoded by the FSCN1 gene.^[5][6][7]

FSCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DFC, 4GP0, 4GP3, 3P53, 4GOY, 4GOV, 3LLP
Identifiers
Aliases	FSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDs	OMIM: 602689; MGI: 1352745; HomoloGene: 48164; GeneCards: FSCN1; OMA:FSCN1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 5,592,816 bp[1] End 5,606,655 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 81.84 cM Start 142,946,098 bp[2] End 142,958,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ganglionic eminence middle frontal gyrus frontal pole Brodmann area 10 C1 segment ventricular zone right frontal lobe putamen Amygdala Top expressed in external carotid artery internal carotid artery abdominal wall Rostral migratory stream endothelial cell of lymphatic vessel condyle primitive streak endocardial cushion fossa mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity actin filament binding protein binding actin binding RNA binding cadherin binding Cellular component cytoplasm cell projection cell-cell junction filopodium ruffle myelin sheath stress fiber microvillus cell junction microspike cell projection membrane actin cytoskeleton podosome extracellular exosome cytoskeleton growth cone lamellipodium filamentous actin cytosol Biological process regulation of microvillus assembly establishment of apical/basal cell polarity regulation of actin cytoskeleton organization actin filament organization cell motility positive regulation of podosome assembly actin filament bundle assembly positive regulation of extracellular matrix disassembly cell-cell junction assembly microspike assembly cell population proliferation positive regulation of lamellipodium assembly cell migration positive regulation of filopodium assembly actin cytoskeleton organization anatomical structure morphogenesis establishment or maintenance of cell polarity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6624 14086 Ensembl ENSG00000075618 ENSMUSG00000029581 UniProt Q16658 Q61553 RefSeq (mRNA) NM_003088 NM_007984 RefSeq (protein) NP_003079 NP_032010 Location (UCSC) Chr 7: 5.59 – 5.61 Mb Chr 5: 142.95 – 142.96 Mb PubMed search [3] [4]
Wikidata
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Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor^[8] and PKC alpha.^[9]