FSTL3

Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.^[5][6][7]

FSTL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KCX, 3B4V, 3SEK
Identifiers
Aliases	FSTL3, FLRG, FSRP, follistatin like 3
External IDs	OMIM: 605343; MGI: 1890391; HomoloGene: 4280; GeneCards: FSTL3; OMA:FSTL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 676,392 bp[1] End 683,392 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,613,106 bp[2] End 79,618,464 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery tibial nerve ascending aorta left coronary artery apex of heart left adrenal cortex left uterine tube upper lobe of left lung gastric mucosa right adrenal gland Top expressed in ascending aorta aortic valve tunica media of zone of aorta umbilical cord morula lip decidua efferent ductule right lung lobe stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding activin binding protein binding Cellular component Golgi apparatus secretory granule nucleoplasm extracellular region neuron projection terminus nucleus extracellular space endoplasmic reticulum lumen Biological process male gonad development regulation of transcription, DNA-templated negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ossification negative regulation of osteoclast differentiation positive regulation of cell-cell adhesion kidney development lung development regulation of transcription by RNA polymerase II adrenal gland development transcription, DNA-templated negative regulation of BMP signaling pathway negative regulation of activin receptor signaling pathway cellular response to metal ion hematopoietic progenitor cell differentiation spermatogenesis positive regulation of transcription by RNA polymerase II post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10272 83554 Ensembl ENSG00000070404 ENSMUSG00000020325 UniProt O95633 Q9EQC7 RefSeq (mRNA) NM_005860 NM_031380 RefSeq (protein) NP_005851 NP_113557 Location (UCSC) Chr 19: 0.68 – 0.68 Mb Chr 10: 79.61 – 79.62 Mb PubMed search [3] [4]
Wikidata
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Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.^[7]