FTSJ1

Putative ribosomal RNA methyltransferase 1 is an enzyme that in humans is encoded by the FTSJ1 gene.^[5][6][7]

FTSJ1
Identifiers
Aliases	FTSJ1, CDLIV, MRX44, MRX9, SPB1, TRMT7, JM23, FtsJ RNA methyltransferase homolog 1 (E. coli), FtsJ RNA methyltransferase homolog 1, FtsJ RNA 2'-O-methyltransferase 1, XLID9
External IDs	OMIM: 300499; MGI: 1859648; HomoloGene: 5372; GeneCards: FTSJ1; OMA:FTSJ1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,476,021 bp[1] End 48,486,364 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A1.1|X 3.73 cM Start 8,104,907 bp[2] End 8,118,645 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium granulocyte body of pancreas ganglionic eminence left uterine tube cerebellar hemisphere right hemisphere of cerebellum right lobe of thyroid gland ascending aorta left adrenal cortex Top expressed in genital tubercle external carotid artery internal carotid artery fetal liver hematopoietic progenitor cell crypt of lieberkuhn of small intestine tail of embryo medial ganglionic eminence hair follicle barrel cortex left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity tRNA (guanosine-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity tRNA methyltransferase activity Cellular component cytosol cytoplasm Biological process methylation RNA methylation tRNA processing tRNA modification cytoplasmic translation tRNA methylation tRNA nucleoside ribose methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24140 54632 Ensembl ENSG00000068438 ENSMUSG00000031171 UniProt Q9UET6 n/a RefSeq (mRNA) NM_001282157 NM_012280 NM_177439 NM_001290430 NM_133991 RefSeq (protein) NP_001269086 NP_036412 NP_803188 n/a Location (UCSC) Chr X: 48.48 – 48.49 Mb Chr X: 8.1 – 8.12 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and may be involved in the processing and modification of rRNA. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[7]