FUSIP1

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.^[5][6][7]

SRSF10
Identifiers
Aliases	SRSF10, FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2, serine/arginine-rich splicing factor 10, serine and arginine rich splicing factor 10
External IDs	OMIM: 605221; MGI: 1333805; HomoloGene: 134051; GeneCards: SRSF10; OMA:SRSF10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 23,964,347 bp[1] End 23,980,927 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 135,583,058 bp[2] End 135,597,219 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone Achilles tendon ganglionic eminence sural nerve tibia gastric mucosa right uterine tube left ovary rectum left lobe of thyroid gland Top expressed in tail of embryo genital tubercle ventricular zone embryo embryo yolk sac neural layer of retina spermatocyte epiblast ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function unfolded protein binding RS domain binding protein binding nucleic acid binding RNA binding Cellular component cytoplasm nucleus nucleoplasm cytosol nuclear speck Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome mRNA processing spliceosomal tri-snRNP complex assembly regulation of transcription, DNA-templated negative regulation of mRNA splicing, via spliceosome mRNA splice site selection mRNA export from nucleus RNA splicing regulation of mRNA splicing, via spliceosome cytosolic transport regulation of RNA splicing regulation of alternative mRNA splicing, via spliceosome mRNA 5'-splice site recognition mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10772 14105 Ensembl ENSG00000188529 ENSMUSG00000028676 UniProt O75494 Q5JRI1 Q9R0U0 RefSeq (mRNA) NM_001191005 NM_001191006 NM_001191007 NM_001191009 NM_001300936 NM_001300937 NM_006625 NM_054016 NM_001080387 NM_001284195 NM_001284196 NM_010178 RefSeq (protein) NP_001177934 NP_001177935 NP_001177936 NP_001177938 NP_001287865 NP_001287866 NP_006616 NP_473357 NP_001287865.1 NP_001073856 NP_001271124 NP_001271125 NP_034308 Location (UCSC) Chr 1: 23.96 – 23.98 Mb Chr 4: 135.58 – 135.6 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.^[7]

Interactions

FUSIP1 has been shown to interact with FUS.^[8]