FUT6

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.^[3][4][5]

FUT6
Identifiers
Aliases	FUT6, FCT3A, FT1A, Fuc-TVI, FucT-VI, fucosyltransferase 6
External IDs	OMIM: 136836; HomoloGene: 34780; GeneCards: FUT6; OMA:FUT6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 5,830,408 bp[1] End 5,839,722 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx olfactory bulb buccal mucosa cell pancreatic ductal cell nasal epithelium mucosa of ileum amniotic fluid trachea oral cavity mucosa of transverse colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity alpha-(1->3)-fucosyltransferase activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity glycosyltransferase activity fucosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus extracellular exosome membrane Golgi membrane Biological process protein glycosylation L-fucose catabolic process fucosylation ceramide metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2528 n/a Ensembl ENSG00000156413 n/a UniProt P51993 n/a RefSeq (mRNA) NM_000150 NM_001040701 NM_001369502 NM_001369504 NM_001369505 NM_001381955 NM_001381956 NM_001381957 NM_001381958 NM_001381959 n/a RefSeq (protein) NP_000141 NP_001035791 NP_001356431 NP_001356433 NP_001356434 NP_001368884 NP_001368885 NP_001368886 NP_001368887 NP_001368888 n/a Location (UCSC) Chr 19: 5.83 – 5.84 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]^[5]