FUT7

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.^[5][6][7]

FUT7
Identifiers
Aliases	FUT7, FucT-VII, fucosyltransferase 7
External IDs	OMIM: 602030; MGI: 107692; HomoloGene: 3296; GeneCards: FUT7; OMA:FUT7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,030,174 bp[1] End 137,032,088 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,313,279 bp[2] End 25,316,386 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb beta cell vena cava body of tongue cardia parotid gland lateral nuclear group of thalamus triceps brachii muscle subthalamic nucleus pericardium Top expressed in granulocyte embryo embryo CA3 field bone marrow thymus lens primary visual cortex duodenum dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity fucosyltransferase activity alpha-(1->3)-fucosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane membrane Golgi membrane Golgi apparatus Biological process leukocyte migration involved in immune response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation L-fucose catabolic process fucosylation ceramide metabolic process protein glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2529 14347 Ensembl ENSG00000180549 ENSMUSG00000036587 UniProt Q11130 Q11131 RefSeq (mRNA) NM_004479 NM_001177366 NM_001177367 NM_001289453 NM_001289454 NM_001289455 NM_001289456 NM_013524 RefSeq (protein) NP_004470 NP_001170837 NP_001170838 NP_001276382 NP_001276383 NP_001276384 NP_001276385 NP_038552 Location (UCSC) Chr 9: 137.03 – 137.03 Mb Chr 2: 25.31 – 25.32 Mb PubMed search [3] [4]
Wikidata
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Function

The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM]^[7]