FUT8

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.^[5][6]

FUT8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DE0
Identifiers
Aliases	FUT8, fucosyltransferase 8, CDGF, CDGF1
External IDs	OMIM: 602589; MGI: 1858901; HomoloGene: 9650; GeneCards: FUT8; OMA:FUT8 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 65,410,592 bp[1] End 65,744,121 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 77,284,899 bp[2] End 77,523,112 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum olfactory bulb testicle trigeminal ganglion inferior ganglion of vagus nerve pylorus ventricular zone C1 segment subthalamic nucleus Achilles tendon Top expressed in seminal vesicula sciatic nerve olfactory epithelium left colon epithelium of stomach crypt of lieberkuhn of small intestine optic nerve lobe of cerebellum olfactory tubercle cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity SH3 domain binding glycoprotein 6-alpha-L-fucosyltransferase activity alpha-(1->6)-fucosyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Golgi cisterna membrane extracellular exosome cytosol Biological process GDP-L-fucose metabolic process regulation of cellular response to oxidative stress N-glycan fucosylation N-glycan processing in utero embryonic development respiratory gaseous exchange by respiratory system protein glycosylation oligosaccharide biosynthetic process regulation of gene expression integrin-mediated signaling pathway protein N-linked glycosylation transforming growth factor beta receptor signaling pathway cell migration L-fucose catabolic process receptor metabolic process protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2530 53618 Ensembl ENSG00000033170 ENSMUSG00000021065 UniProt Q9BYC5 Q9WTS2 RefSeq (mRNA) NM_004480 NM_178154 NM_178155 NM_178156 NM_178157 NM_001371533 NM_001371534 NM_001371536 NM_001252614 NM_001252615 NM_001252616 NM_016893 RefSeq (protein) NP_004471 NP_835368 NP_835369 NP_001358462 NP_001358463 NP_001358465 NP_001239543 NP_001239544 NP_001239545 NP_058589 Location (UCSC) Chr 14: 65.41 – 65.74 Mb Chr 12: 77.28 – 77.52 Mb PubMed search [3] [4]
Wikidata
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This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition to existing oligosaccharides or the four Protein O-fucosyltransferases (POFUTs) that transfer fucose in alpha1-O linkage directly to serines or threonines in specific protein motifs. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.^[6]

Kyowa Hakko Kirin's "Potelligent" platform uses a CHO cell line in which FUT8 has been knocked out to make afucosylated monoclonal antibodies.^[7]