Far upstream element-binding protein 1

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.^[5][6]

FUBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J4W, 2KXH, 4LIJ
Identifiers
Aliases	FUBP1, FBP, FUBP, hDH V, far upstream element binding protein 1
External IDs	OMIM: 603444; MGI: 1196294; HomoloGene: 48253; GeneCards: FUBP1; OMA:FUBP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 77,944,055 bp[1] End 77,979,110 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H3|3 77.05 cM Start 151,916,059 bp[2] End 151,942,463 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence Achilles tendon left ovary right uterine tube right ovary body of uterus left lobe of thyroid gland right lobe of thyroid gland canal of the cervix Top expressed in genital tubercle tail of embryo ventricular zone maxillary prominence mandibular prominence epiblast somite abdominal wall ganglionic eminence Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding single-stranded DNA binding DNA-binding transcription factor activity DNA binding RNA binding Cellular component nucleus nucleoplasm Biological process positive regulation of gene expression regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8880 51886 Ensembl ENSG00000162613 ENSMUSG00000028034 UniProt Q96AE4 Q91WJ8 RefSeq (mRNA) NM_001303433 NM_003902 NM_001376055 NM_001376056 NM_001376057 NM_057172 NM_001355366 NM_001355367 NM_001355368 NM_001355369 NM_001355370 NM_001355371 NM_001355372 NM_001355373 NM_001355374 RefSeq (protein) NP_001290362 NP_003893 NP_001362984 NP_001362985 NP_001362986 NP_476513 NP_001342295 NP_001342296 NP_001342297 NP_001342298 NP_001342299 NP_001342300 NP_001342301 NP_001342302 NP_001342303 Location (UCSC) Chr 1: 77.94 – 77.98 Mb Chr 3: 151.92 – 151.94 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.^[6]

Interactions

Far upstream element-binding protein 1 has been shown to interact with MAPK14^[7] and SMN1.^[8]

Clinical Significance

FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.^[9] CIC gene is also lost in the 1p/19q codeletion mutation.