Fas associated factor family member 2

Fas associated factor family member 2 is a protein that in humans is encoded by the FAF2 gene. ^[5]

FAF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DAM
Identifiers
Aliases	FAF2, ETEA, UBXD8, UBXN3B, Fas associated factor family member 2
External IDs	OMIM: 616935; MGI: 1923827; HomoloGene: 8753; GeneCards: FAF2; OMA:FAF2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,447,628 bp[1] End 176,510,074 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 54,769,597 bp[2] End 54,811,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland gingival epithelium tibia caput epididymis corpus epididymis tail of epididymis parietal pleura visceral pleura inferior olivary nucleus islet of Langerhans Top expressed in spermatocyte spermatid yolk sac right kidney otolith organ interventricular septum utricle tail of embryo neural tube genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function lipase inhibitor activity ubiquitin binding protein binding lipase binding ubiquitin protein ligase binding Cellular component VCP-NPL4-UFD1 AAA ATPase complex cytoplasm lipid droplet endoplasmic reticulum extracellular region azurophil granule lumen Biological process response to unfolded protein retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway lipid droplet organization negative regulation of catalytic activity neutrophil degranulation proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23197 76577 Ensembl ENSG00000113194 ENSMUSG00000025873 UniProt Q96CS3 Q3TDN2 RefSeq (mRNA) NM_014613 NM_178397 RefSeq (protein) NP_055428 NP_848484 Location (UCSC) Chr 5: 176.45 – 176.51 Mb Chr 13: 54.77 – 54.81 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008].