Fc receptor-like molecule

Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number of species, including humans and mice. A subset of FCRLs are preferentially expressed by B lymphocytes. Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. Their function is unknown.^[1]

It has been indicated that FCRLs may be a unique marker for immune cells in the brain called microglia, compared to other CNS cells and peripheral immune cells.^[2]

Members

• FCRL1
• FCRL2
• FCRL3
• FCRL4
• FCRL5
• FCRL6
• FCRLA. FCRLA associates with IgM, IgG and IgA.^[3]
• FCRLB

See also

• Fc receptor