Fibrinogen alpha chain

Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.

FGA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BBR, 1DM4, 1FPH, 1FZA, 1FZB, 1FZC, 1FZD, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 1YCP, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3AT0, 3BVH, 3E1I, 3GHG, 3H32, 3HUS, 4F27, 5CFA
Identifiers
Aliases	FGA, Fib2, fibrinogen alpha chain
External IDs	OMIM: 134820; MGI: 1316726; HomoloGene: 428; GeneCards: FGA; OMA:FGA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 154,583,128 bp[1] End 154,590,745 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E3|3 36.96 cM Start 82,933,383 bp[2] End 82,940,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver islet of Langerhans beta cell body of stomach testicle fundus decidua cerebellar vermis cardia body of pancreas Top expressed in left lobe of liver gallbladder human fetus yolk sac fetal liver hematopoietic progenitor cell right kidney proximal tubule sexually immature organism human kidney epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity structural molecule activity metal ion binding protein binding signaling receptor binding cell adhesion molecule binding Cellular component platelet alpha granule extracellular vesicle plasma membrane fibrinogen complex extracellular region cell surface cell cortex extracellular exosome platelet alpha granule lumen external side of plasma membrane blood microparticle extracellular space endoplasmic reticulum lumen Biological process hemostasis negative regulation of endothelial cell apoptotic process positive regulation of peptide hormone secretion protein polymerization positive regulation of heterotypic cell-cell adhesion adaptive immune response fibrinolysis immune system process platelet degranulation blood coagulation extracellular matrix organization response to calcium ion positive regulation of substrate adhesion-dependent cell spreading blood coagulation, common pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of vasoconstriction positive regulation of protein secretion positive regulation of ERK1 and ERK2 cascade negative regulation of blood coagulation, common pathway positive regulation of exocytosis blood coagulation, fibrin clot formation plasminogen activation cell-matrix adhesion innate immune response platelet aggregation signal transduction induction of bacterial agglutination platelet activation toll-like receptor signaling pathway post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2243 14161 Ensembl ENSG00000171560 ENSMUSG00000028001 UniProt P02671 E9PV24 RefSeq (mRNA) NM_000508 NM_021871 NM_001111048 NM_010196 RefSeq (protein) NP_000499 NP_068657 NP_001104518 NP_034326 Location (UCSC) Chr 4: 154.58 – 154.59 Mb Chr 3: 82.93 – 82.94 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.^[5]

Interactions

Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator.^[6][7]

See also

• Fibrinogen gamma chain