Fourphit

Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist.^[1][2] It blocks the binding of methylphenidate to the DAT in vitro,^[1] though apparently not in vivo.^[2] In any case, the drug reduces the stimulant-like effects of cocaine in animals,^[2] whilst producing mostly negligible behavioral effects itself.^[2] Fourphit is an acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).^[1]

Fourphit

Clinical data
Other names	4-Isothiocyanato-PCP
Drug class	Irreversible dopamine transporter blocker; Reversible NMDA receptor antagonist; Psychostimulant antagonist
Identifiers
IUPAC name 4-isothiocyanato-1-(1-phenylcyclohexyl)piperidine
CAS Number	104639-01-2 Y
PubChem CID	128615
ChemSpider	113988
UNII	EP455HL5XL
CompTox Dashboard (EPA)	DTXSID10146625
Chemical and physical data
Formula	C18H24N2S
Molar mass	300.46 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CCC(CC1)(C2=CC=CC=C2)N3CCC(CC3)N=C=S
InChI InChI=1S/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2 Key:QAHYIAVTWZVTMY-UHFFFAOYSA-N

See also

• RTI-76
• p-ISOCOC
• Methocinnamox