Fructosamine-3-kinase

Fructosamine-3-kinase is an enzyme that in humans is encoded by the FN3K gene.^[5][6][7]

FN3K
Identifiers
Aliases	FN3K, fructosamine 3 kinase
External IDs	OMIM: 608425; MGI: 1926834; HomoloGene: 23336; GeneCards: FN3K; OMA:FN3K - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,735,615 bp[1] End 82,751,196 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 121,325,739 bp[2] End 121,341,317 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve C1 segment left adrenal cortex right adrenal cortex anterior cingulate cortex right hemisphere of cerebellum right frontal lobe apex of heart prefrontal cortex right auricle of heart Top expressed in interventricular septum facial motor nucleus anterior horn of spinal cord fetal liver hematopoietic progenitor cell epithelium of lens medial vestibular nucleus inferior colliculi medial dorsal nucleus superior frontal gyrus deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity kinase activity Cellular component cytosol cellular component Biological process post-translational protein modification epithelial cell differentiation fructoselysine metabolic process phosphorylation fructosamine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64122 63828 Ensembl ENSG00000167363 ENSMUSG00000025175 UniProt Q9H479 Q9ER35 RefSeq (mRNA) NM_022158 NM_001038699 NM_022014 RefSeq (protein) NP_071441 NP_001033788 NP_071297 Location (UCSC) Chr 17: 82.74 – 82.75 Mb Chr 11: 121.33 – 121.34 Mb PubMed search [3] [4]
Wikidata
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Function

FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins.^[7][8]

FN3K is responsible for the formation of fructose 3-phosphate (F3P), a compound identified in the lenses of diabetic rats. The spontaneous decomposition of F3P leads to the formation of 3-deoxyglucosone (3DG). 3DG contributes to diabetic complications. Treatment of normal and diabetic rats with an inhibitor of FN3K demonstrated a large reduction (~50%) in systemic 3DG in both groups. Removal of 3DG at its source by inhibition of FN3K is a viable option to treat diabetes related diseases since it would require a much smaller dose of drug.