G3BP2

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene.^[5][6][7]

G3BP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DRV
Identifiers
Aliases	G3BP2, G3BP stress granule assembly factor 2
External IDs	MGI: 2442040; HomoloGene: 137244; GeneCards: G3BP2; OMA:G3BP2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,641,849 bp[1] End 75,724,589 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,200,005 bp[2] End 92,231,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus islet of Langerhans Achilles tendon frontal pole Pons pars compacta lateral nuclear group of thalamus Skeletal muscle tissue of rectus abdominis germinal epithelium epithelium of colon Top expressed in zygote secondary oocyte tail of embryo blood anterior horn of spinal cord genital tubercle nucleus accumbens primary oocyte abdominal wall facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor complex adaptor activity protein binding nucleic acid binding mRNA binding RNA binding Cellular component intracellular anatomical structure cytoplasm cytosol ribonucleoprotein complex cytoplasmic stress granule Biological process mRNA transport Ras protein signal transduction cytoplasmic sequestering of NF-kappaB stress granule assembly transport positive regulation of signal transduction viral process protein homooligomerization positive regulation of stress granule assembly immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9908 23881 Ensembl ENSG00000138757 ENSMUSG00000029405 UniProt Q9UN86 P97379 RefSeq (mRNA) NM_012297 NM_203504 NM_203505 NM_001080794 NM_001080795 NM_001080796 NM_001080797 NM_011816 NM_001359195 NM_001359196 NM_001359197 RefSeq (protein) NP_036429 NP_987100 NP_987101 NP_987100.1 NP_001074263 NP_001074264 NP_001074265 NP_001074266 NP_035946 NP_001346124 NP_001346125 NP_001346126 Location (UCSC) Chr 4: 75.64 – 75.72 Mb Chr 5: 92.2 – 92.23 Mb PubMed search [3] [4]
Wikidata
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Interactions

G3BP2 has been shown to interact with IκBα.^[8]