G6B

Protein G6b is a protein that in humans is encoded by the G6B gene, or C6orf25.^[5][6][7]

MPIG6B
Identifiers
Aliases	MPIG6B, G6b, NG31, C6orf25, G6B, chromosome 6 open reading frame 25, G6b-B, megakaryocyte and platelet inhibitory receptor G6b, THAMY
External IDs	OMIM: 606520; MGI: 2146995; HomoloGene: 82249; GeneCards: MPIG6B; OMA:MPIG6B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,718,594 bp[1] End 31,726,714 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,281,669 bp[2] End 35,285,160 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte bone marrow cells skin of leg skin of abdomen testicle right lung epithelium of colon spleen Top expressed in bone marrow spleen embryo blastocyst lip morula ventricle of the heart testicle epiblast zone of skin More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding protein binding Cellular component integral component of membrane plasma membrane endoplasmic reticulum membrane Golgi apparatus Biological process platelet activation negative regulation of signal transduction integrin-mediated signaling pathway blood coagulation erythrocyte differentiation megakaryocyte differentiation platelet formation megakaryocyte development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80739 106722 Ensembl ENSG00000206396 ENSG00000224393 ENSG00000204420 ENSG00000237459 ENSG00000230060 ENSG00000228090 ENSG00000231003 ENSMUSG00000073414 UniProt O95866 D7PDD4 RefSeq (mRNA) NM_025260 NM_138272 NM_138273 NM_138274 NM_138275 NM_138276 NM_138277 NM_001033221 NM_001191012 RefSeq (protein) NP_079536 NP_612116 NP_612117 NP_612118 NP_612119 NP_612121 NP_079536.2 NP_612116.1 NP_612117.1 NP_612118.1 NP_612119.1 NP_612121.1 NP_001028393 NP_001177941 Location (UCSC) Chr 6: 31.72 – 31.73 Mb Chr 17: 35.28 – 35.29 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]