G6PC2

Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene.^[5][6][7]

G6PC2
Identifiers
Aliases	G6PC2, IGRP, glucose-6-phosphatase catalytic subunit 2
External IDs	OMIM: 608058; MGI: 1277193; HomoloGene: 41423; GeneCards: G6PC2; OMA:G6PC2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 168,901,291 bp[1] End 168,910,000 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C2|2 39.66 cM Start 69,041,417 bp[2] End 69,058,185 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans body of pancreas duodenum left testis right testis Achilles tendon white blood cell myeloid leukocyte monocyte liver Top expressed in islet of Langerhans embryo tail of embryo vas deferens right ventricle renal corpuscle tracheobronchial tree trachea spinal ganglia prostate More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity glucose-6-phosphatase activity Cellular component membrane integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum Biological process glucose 6-phosphate metabolic process glucose homeostasis regulation of insulin secretion dephosphorylation gluconeogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57818 14378 Ensembl ENSG00000278373 ENSG00000152254 ENSMUSG00000005232 UniProt Q9NQR9 Q9Z186 RefSeq (mRNA) NM_001081686 NM_021176 NM_001289856 NM_001289857 NM_021331 RefSeq (protein) NP_001075155 NP_066999 NP_001276785 NP_001276786 NP_067306 Location (UCSC) Chr 2: 168.9 – 168.91 Mb Chr 2: 69.04 – 69.06 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.^[7]