GABARAP

Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene.^[5]

GABARAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GNU, 1KLV, 1KM7, 1KOT, 3D32, 3DOW, 3WIM, 4XC2
Identifiers
Aliases	GABARAP, ATG8A, GABARAP-a, MM46, GABA type A receptor-associated protein
External IDs	OMIM: 605125; MGI: 1861742; HomoloGene: 134119; GeneCards: GABARAP; OMA:GABARAP - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,240,008 bp[1] End 7,242,449 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.95 cM Start 69,881,969 bp[2] End 69,885,777 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis pituitary gland anterior pituitary monocyte right adrenal gland blood right adrenal cortex left adrenal cortex C1 segment Top expressed in molar calvaria granulocyte parotid gland seminal vesicula optic nerve spermatid atrium blood efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding beta-tubulin binding ubiquitin protein ligase binding GABA receptor binding Cellular component cytoplasm cell body Golgi apparatus membrane Golgi membrane plasma membrane microtubule associated complex smooth endoplasmic reticulum autophagosome autophagosome membrane actin cytoskeleton perinuclear region of cytoplasm axoneme lysosome sperm midpiece cytoskeleton microtubule cytoplasmic vesicle endomembrane system cytosol Biological process chemical synaptic transmission protein targeting autophagy protein transport macroautophagy microtubule cytoskeleton organization extrinsic apoptotic signaling pathway via death domain receptors apoptotic process autophagosome maturation autophagosome assembly autophagy of mitochondrion cellular response to nitrogen starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11337 56486 Ensembl ENSG00000170296 ENSMUSG00000018567 UniProt O95166 Q9DCD6 RefSeq (mRNA) NM_007278 NM_019749 RefSeq (protein) NP_009209 NP_062723 Location (UCSC) Chr 17: 7.24 – 7.24 Mb Chr 11: 69.88 – 69.89 Mb PubMed search [3] [4]
Wikidata
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Function

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.^[6]

Moreover, GABARAP has an important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of cytosolic cargo into double-membrane vesicles, leading to subsequent degradation after fusion with lysosomes.^[7] In addition, GABARAP can mediate selective autophagy because it binds to so-called autophagic receptors (e.g. p62, NBr1), which bind and recruit specific cargo.

Interactions

GABARAP has been shown to interact with TFRC,^[8] ULK1^[9][10] and GABRG2.^[5][11][12] A bound structure for GABARAP to GABRG2 consistent with experimental observations has been computationally derived.^[13]