GABRE

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.^[3][4][5]

GABRE
Identifiers
Aliases	GABRE, gamma-aminobutyric acid type A receptor epsilon subunit, gamma-aminobutyric acid type A receptor subunit epsilon
External IDs	OMIM: 300093; HomoloGene: 68425; GeneCards: GABRE; OMA:GABRE - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 151,953,124 bp[1] End 151,974,680 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vagina subcutaneous adipose tissue apex of heart ectocervix canal of the cervix skin of abdomen minor salivary glands skin of leg popliteal artery tibial arteries n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-gated chloride ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity inhibitory extracellular ligand-gated ion channel activity benzodiazepine receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane cell junction postsynaptic membrane plasma membrane synapse membrane chloride channel complex GABA-A receptor complex integral component of plasma membrane dendrite membrane neuron projection postsynapse Biological process ion transmembrane transport chloride transport chloride transmembrane transport ion transport negative regulation of chloride transport signal transduction gamma-aminobutyric acid signaling pathway chemical synaptic transmission regulation of membrane potential nervous system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2564 n/a Ensembl ENSG00000102287 n/a UniProt P78334 n/a RefSeq (mRNA) NM_004961 NM_021984 NM_021987 NM_021990 n/a RefSeq (protein) NP_004952 n/a Location (UCSC) Chr X: 151.95 – 151.97 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Brainstem expression of ε subunit-containing GABA_A receptors is upregulated during pregnancy, particularly in the ventral respiratory group.^[6]

See also

• GABAA receptor