GABRG1

Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene.^[5] The protein encoded by this gene is a subunit of the GABAA receptor.^[6]

GABRG1
Identifiers
Aliases	GABRG1, gamma-aminobutyric acid type A receptor gamma1 subunit, gamma-aminobutyric acid type A receptor subunit gamma1
External IDs	OMIM: 137166; MGI: 103156; HomoloGene: 22570; GeneCards: GABRG1; OMA:GABRG1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p12 Start 46,035,769 bp[1] End 46,124,054 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.1|5 37.43 cM Start 70,908,390 bp[2] End 70,999,960 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus endothelial cell external globus pallidus Brodmann area 23 entorhinal cortex caudate nucleus nucleus accumbens Amygdala Brodmann area 46 Hypothalamus Top expressed in paraventricular nucleus of hypothalamus ventromedial nucleus lateral septal nucleus dorsomedial hypothalamic nucleus arcuate nucleus suprachiasmatic nucleus median eminence lateral hypothalamus globus pallidus mammillary body More reference expression data BioGPS n/a
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity GABA receptor binding inhibitory extracellular ligand-gated ion channel activity benzodiazepine receptor activity GABA-gated chloride ion channel activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane cell junction postsynaptic membrane plasma membrane receptor complex synapse membrane chloride channel complex integral component of plasma membrane dendrite membrane neuron projection postsynapse GABA-A receptor complex Biological process gamma-aminobutyric acid signaling pathway ion transmembrane transport chloride transport chloride transmembrane transport ion transport chemical synaptic transmission signal transduction regulation of membrane potential nervous system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2565 14405 Ensembl ENSG00000163285 ENSMUSG00000001260 UniProt Q8N1C3 Q9R0Y8 RefSeq (mRNA) NM_173536 NM_010252 RefSeq (protein) NP_775807 NP_034382 Location (UCSC) Chr 4: 46.04 – 46.12 Mb Chr 5: 70.91 – 71 Mb PubMed search [3] [4]
Wikidata
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Variants of this gene may be associated with alcohol dependence.^[7]