GABRG3

GABA_A receptor-γ3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene.

GABRG3
Identifiers
Aliases	GABRG3, gamma-aminobutyric acid type A receptor gamma3 subunit, gamma-aminobutyric acid type A receptor subunit gamma3
External IDs	OMIM: 600233; MGI: 95624; HomoloGene: 22444; GeneCards: GABRG3; OMA:GABRG3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q12 Start 26,971,181 bp[1] End 27,541,984 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B5|7 33.48 cM Start 56,366,213 bp[2] End 57,036,936 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis prefrontal cortex gonad anterior pituitary sperm Brodmann area 9 Hypothalamus cingulate gyrus Top expressed in epithelium of lens lumbar subsegment of spinal cord nucleus accumbens superior frontal gyrus lateral septal nucleus dorsal striatum prefrontal cortex dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity inhibitory extracellular ligand-gated ion channel activity benzodiazepine receptor activity GABA-gated chloride ion channel activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane cell junction plasma membrane postsynaptic membrane synapse membrane chloride channel complex GABA-ergic synapse integral component of synaptic membrane integral component of plasma membrane dendrite membrane neuron projection postsynapse GABA-A receptor complex Biological process gamma-aminobutyric acid signaling pathway chloride transport chloride transmembrane transport ion transport ion transmembrane transport signal transduction chemical synaptic transmission regulation of membrane potential nervous system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2567 14407 Ensembl ENSG00000182256 ENSMUSG00000055026 UniProt Q99928 P27681 RefSeq (mRNA) NM_001270873 NM_033223 NM_008074 NM_177273 RefSeq (protein) NP_001257802 NP_150092 NP_032100 Location (UCSC) Chr 15: 26.97 – 27.54 Mb Chr 7: 56.37 – 57.04 Mb PubMed search [3] [4]
Wikidata
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Function

GABRG3 is a subunit of the GABA_A receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).^[5]

Association with alcoholism

Genetic markers near the GABRG3 gene are statistically linked to alcoholism.^[6]

See also

• GABAA receptor