GABRR1

Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.^[5][6][7]

GABRR1
Identifiers
Aliases	GABRR1, gamma-aminobutyric acid type A receptor rho1 subunit, gamma-aminobutyric acid type A receptor subunit rho1
External IDs	OMIM: 137161; MGI: 95625; HomoloGene: 20470; GeneCards: GABRR1; OMA:GABRR1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,177,504 bp[1] End 89,231,278 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 14.68 cM Start 33,132,521 bp[2] End 33,163,588 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad Descending thoracic aorta ascending aorta pancreatic ductal cell tibialis anterior muscle deltoid muscle tibial arteries left coronary artery right coronary artery Top expressed in neural layer of retina embryo embryo muscle of thigh epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection glutamatergic synapse GABA-ergic synapse Biological process gamma-aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport chemical synaptic transmission ion transmembrane transport signal transduction regulation of membrane potential nervous system process regulation of postsynaptic membrane potential regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2569 14408 Ensembl ENSG00000146276 ENSMUSG00000028280 UniProt P24046 P56475 RefSeq (mRNA) NM_001256703 NM_001256704 NM_001267582 NM_002042 NM_008075 RefSeq (protein) NP_001243632 NP_001243633 NP_001254511 NP_002033 NP_032101 Location (UCSC) Chr 6: 89.18 – 89.23 Mb Chr 4: 33.13 – 33.16 Mb PubMed search [3] [4]
Wikidata
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.^[7]

See also

• GABA_A-ρ receptor